Title : Atomic basis for the species-specific inhibition of αV integrins by monoclonal antibody 17E6 is revealed by the crystal structure of αVβ3 ectodomain-17E6 Fab complex.

Pub. Date : 2014 May 16

PMID : 24692540






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The Propeller residue Asp-150, which normally coordinates Arg of the ligand Arg-Gly-Asp motif, formed contacts with Arg-54 of the Fab that were expected to reduce soluble FN10 binding to cellular alphaVbeta3 complexed with 17E6. Glycine FA complementation group B Homo sapiens