Pub. Date : 2014 May 14
PMID : 24685584
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug-drug interaction in rats. | Anthraquinones | solute carrier family 22 member 6 | Homo sapiens |
| 2 | Interaction of five anthraquinones from rhubarb with human organic anion transporter 1 (SLC22A6) and 3 (SLC22A8) and drug-drug interaction in rats. | Anthraquinones | solute carrier family 22 member 6 | Homo sapiens |
| 3 | MATERIALS AND METHODS: Here we studied the interaction of five anthraquinone derivatives with human renal organic anion transporter 1 (hOAT1) and hOAT3 stably expressed in cells, and interaction of rhein or rhubarb extract (RE) with furosemide (FS, substrate of OATs) in rats. | Anthraquinones | solute carrier family 22 member 6 | Homo sapiens |
| 4 | MATERIALS AND METHODS: Here we studied the interaction of five anthraquinone derivatives with human renal organic anion transporter 1 (hOAT1) and hOAT3 stably expressed in cells, and interaction of rhein or rhubarb extract (RE) with furosemide (FS, substrate of OATs) in rats. | Anthraquinones | solute carrier family 22 member 6 | Homo sapiens |
| 5 | CONCLUSIONS: These findings suggested that five anthraquinones inhibited hOAT1 and hOAT3, but these compounds were not transported by hOAT1 or hOAT3. | Anthraquinones | solute carrier family 22 member 6 | Homo sapiens |