Pub. Date : 2014 Apr 10
PMID : 24685134
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. | Iron | tumor protein p53 | Homo sapiens |
| 2 | Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. | Iron | tumor protein p53 | Homo sapiens |
| 3 | Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function. | Iron | tumor protein p53 | Homo sapiens |
| 4 | Here, we report that the tumor suppressor protein p53 is downregulated during iron excess. | Iron | tumor protein p53 | Homo sapiens |
| 5 | Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation. | Iron | tumor protein p53 | Homo sapiens |
| 6 | Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation. | Iron | tumor protein p53 | Homo sapiens |
| 7 | Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation. | Iron | tumor protein p53 | Homo sapiens |
| 8 | Moreover, in a tumorigenicity assay, iron deprivation suppressed wild-type p53-dependent tumor growth, suggesting that upregulation of wild-type p53 signaling underlies the selective efficacy of iron deprivation. | Iron | tumor protein p53 | Homo sapiens |
| 9 | Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy. | Iron | tumor protein p53 | Homo sapiens |
| 10 | Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy. | Iron | tumor protein p53 | Homo sapiens |
| 11 | Our findings thus identify a direct link between iron/heme homeostasis and the regulation of p53 signaling, which not only provides mechanistic insights into iron-excess-associated tumorigenesis but may also help predict and improve outcomes in iron-deprivation-based chemotherapy. | Iron | tumor protein p53 | Homo sapiens |