Pub. Date : 2014 Jun
PMID : 24681041
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MicroRNA-216b/Beclin 1 axis regulates autophagy and apoptosis in human Tenon"s capsule fibroblasts upon hydroxycamptothecin exposure. | hydroxycamptothecinum | microRNA 216b | Homo sapiens |
| 2 | We showed that HCPT induced significant autophagy as well as apoptosis, two self-destructive processes, and down-regulated the expression of miR-216b in HTFs. | hydroxycamptothecinum | microRNA 216b | Homo sapiens |
| 3 | Overexpression of miR-216b in HTFs suppressed the autophagy and apoptosis induced by HCPT, whereas silence of miR-216b led to effects that were similar to those caused by the treatment with HCPT. | hydroxycamptothecinum | microRNA 216b | Homo sapiens |
| 4 | Altogether, we concluded that miR-216b regulated both autophagy and apoptosis by modulating Beclin 1 in HTFs treated with HCPT. | hydroxycamptothecinum | microRNA 216b | Homo sapiens |