Title : [Simvastatin attenuates oxidized low density lipoprotein induced oxidative stress in human umbilical vein endothelial cells via downregulating NADPH oxidase activity].

Pub. Date : 2014 Jan

PMID : 24680269






3 Functional Relationships(s)
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1 In addition, simvastatin significantly downregulated mRNA expression of p22(phox), gp91(phox), p47(phox) and p67(phox) (all P < 0.05), as well as the interaction of p47(phox)/p22(phox) (P < 0.01). Simvastatin calcineurin like EF-hand protein 1 Homo sapiens
2 In addition, simvastatin significantly downregulated mRNA expression of p22(phox), gp91(phox), p47(phox) and p67(phox) (all P < 0.05), as well as the interaction of p47(phox)/p22(phox) (P < 0.01). Simvastatin calcineurin like EF-hand protein 1 Homo sapiens
3 CONCLUSIONS: Simvastatin is an important regulator on NADPH subunits mRNA expressions and p47(phox)/p22(phox) interaction. Simvastatin calcineurin like EF-hand protein 1 Homo sapiens