Title : 5-methylcytosine recognition by Arabidopsis thaliana DNA glycosylases DEMETER and DML3.

Pub. Date : 2014 Apr 22

PMID : 24678721






2 Functional Relationships(s)
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1 Although the related Repressor of Silencing 1 (ROS1) enzyme has been characterized, the molecular basis for 5mC recognition by DME has not been investigated. 5-Methylcytosine demeter-like 1 Arabidopsis thaliana
2 Our results indicate that the 5mC binding pocket is composed of residues from discrete domains and is responsible for discrimination against 5mC derivatives, and suggest that DME, ROS1, and DML3 utilize subtly different mechanisms to probe the DNA duplex for cytosine modifications. 5-Methylcytosine demeter-like 1 Arabidopsis thaliana