Pub. Date : 2014
PMID : 24678242
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Host Cell Reactivation and Transcriptional Activation of Carboplatin-Modified BRCA1. | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |
| 2 | BRCA1 damaged by carboplatin treatment may lead to a loss of such functions. | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |
| 3 | A reduction in cellular BRCA1 repair of carboplatin-treated plasmid DNA, using a host cell reactivation assay, was dependent on the platination levels on the reporter gene. | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |
| 4 | The transcriptional transactivation activity of the drug-modified BRCA1, assessed using a one-hybrid GAL4 transcriptional assay, was inversely proportional to the carboplatin doses. | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |
| 5 | The data emphasized the potential of the BRCA1 gene to be a target for carboplatin treatment. | Carboplatin | BRCA1 DNA repair associated | Homo sapiens |