Pub. Date : 2014 Jun
PMID : 24675090
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mice are resistant to aflatoxin hepatotoxicity, primarily due to high expression of glutathione S-transferases (GSTs), and in particular the GSTA3 subunit. | Aflatoxins | glutathione S-transferase, alpha 3 | Mus musculus |
| 2 | Mice are resistant to aflatoxin hepatotoxicity, primarily due to high expression of glutathione S-transferases (GSTs), and in particular the GSTA3 subunit. | Aflatoxins | glutathione S-transferase, alpha 3 | Mus musculus |
| 3 | Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling, which controls a broad-based cytoprotective response, was activated either genetically or pharmacologically in an attempt to rescue GSTA3 knockout mice from aflatoxin genotoxicity. | Aflatoxins | glutathione S-transferase, alpha 3 | Mus musculus |
| 4 | The inability to rescue GSTA3 knockout mice from aflatoxin genotoxicity through the Nrf2 transcriptional program indicates that Gsta3 is unilaterally responsible for the detoxication of aflatoxin in mice. | Aflatoxins | glutathione S-transferase, alpha 3 | Mus musculus |