Title : The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A₂ via GPR120 receptor to produce prostaglandin E₂ and plays an anti-inflammatory role in macrophages.

Pub. Date : 2014 Sep

PMID : 24673159






2 Functional Relationships(s)
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1 We report here that DHA and the GPR120 agonist, GW9508, activate cPLA2 and cyclooxygenase 2 (COX-2), and cause prostaglandin E2 (PGE2) release in a murine macrophage cell line RAW264.7 and in human primary monocyte-derived macrophages. GW9508 free fatty acid receptor 4 Mus musculus
2 DHA and GW9508 activate cPLA2 via GPR120 receptor, G protein Galphaq and scaffold protein beta-arrestin 2. GW9508 free fatty acid receptor 4 Mus musculus