Title : Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy.

Pub. Date : 2014 Mar 26

PMID : 24670789






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 CA-II is activated by high glucose levels and directly induces cardiomyocyte hypertrophy and death in vitro, which are prevented by sodium-hydrogen exchanger-1 inhibition. Glucose carbonic anhydrase 2 Homo sapiens
2 MicroRNA-23b is regulated by p38 mitogen-activated protein kinase, and it modulates high-glucose CA-II-dependent effects on cardiomyocyte survival in vitro. Glucose carbonic anhydrase 2 Homo sapiens