Title : Carvedilol induces greater control of β2- than β 1-adrenoceptor-mediated inotropic and lusitropic effects by PDE3, while PDE4 has no effect in human failing myocardium.

Pub. Date : 2014 Jul

PMID : 24668024






1 Functional Relationships(s)
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1 The effects of (-)-noradrenaline, mediated through beta1-adrenoceptors (beta2-adrenoceptors blocked with ICI118551), and (-)-adrenaline, mediated through beta2-adrenoceptors (beta1-adrenoceptors blocked with CGP20712A), were assessed in the absence and presence of the PDE inhibitors. Norepinephrine potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens