Title : Different phosphatidylinositol 3-phosphate asymmetries in yeast and mammalian autophagosomes revealed by a new electron microscopy technique.

Pub. Date : 2014 May

PMID : 24667433






2 Functional Relationships(s)
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1 In yeast deleted for 2 cytoplasmic PtdIns3P phosphatases, Ymr1 and Sjl3, PtdIns3P distributed in an equivalent density in the 2 leaflets of the autophagosome membrane, suggesting that the asymmetry in wild-type yeast is generated as a result of unilateral PtdIns3P hydrolysis. phosphatidylinositol 3-phosphate phosphatidylinositol-3-phosphatase YMR1 Saccharomyces cerevisiae S288C
2 In yeast deleted for 2 cytoplasmic PtdIns3P phosphatases, Ymr1 and Sjl3, PtdIns3P distributed in an equivalent density in the 2 leaflets of the autophagosome membrane, suggesting that the asymmetry in wild-type yeast is generated as a result of unilateral PtdIns3P hydrolysis. phosphatidylinositol 3-phosphate phosphatidylinositol-3-phosphatase YMR1 Saccharomyces cerevisiae S288C