Title : Effects of LPS and dietary free fatty acids on MCP-1 in 3T3-L1 adipocytes and macrophages in vitro.

Pub. Date : 2014 Mar 24

PMID : 24662749






2 Functional Relationships(s)
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1 In macrophages, palmitic acid increased MCP-1 mRNA expression by 1.8-fold (P<0.05), but oleic acid and elaidic acid had no effects. Palmitic Acid C-C motif chemokine ligand 2 Homo sapiens
2 The different classes of FFA did not induce MCP-1 mRNA expression or protein secretion in the adipocytes, but the saturated FFA, palmitic acid, induced MCP-1 mRNA expression in macrophages, possibly because of the higher expression level of TLR4 in the macrophages than the adipocytes. Palmitic Acid C-C motif chemokine ligand 2 Homo sapiens