Title : Protein kinase C (PKC) changes in human basophils. IgE-mediated activation is accompanied by an increase in total PKC activity.

Pub. Date : 1989 Mar 1

PMID : 2465345






3 Functional Relationships(s)
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1 Exposure to 0.1 microgram/ml anti-IgE resulted in an increase in total cellular PKC (169 +/- 23% of control, histamine release (HR) = 33 +/- 7%, n = 12) which could be accounted for solely by the increase in membrane-associated PKC. Histamine proline rich transmembrane protein 2 Homo sapiens
2 We found a good correlation between the increase in membrane-associated PKC and the eventual release of histamine (rs = 0.902). Histamine proline rich transmembrane protein 2 Homo sapiens
3 Donors whose basophils released less than 5% total histamine (n = 3, HR = 3 +/- 1%) showed a partial activation of PKC (173 +/- 18%) though much less than the remaining donors (increase in PKC = 346 +/- 59%, n = 9, HR = 43 +/- 7%). Histamine proline rich transmembrane protein 2 Homo sapiens