Title : Mode of action of erythropoietin (Epo) in an Epo-dependent murine cell line. I. Involvement of adenosine 3',5'-cyclic monophosphate not as a second messenger but as a regulator of cell growth.

Pub. Date : 1989 Mar

PMID : 2465166






3 Functional Relationships(s)
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1 In initial experiments, cAMP levels in cells stimulated with either recombinant Epo or recombinant IL-3 were monitored. Cyclic AMP erythropoietin Mus musculus
2 The regulatory effects of cAMP on Epo- and IL-3-stimulated cell growth were next examined. Cyclic AMP erythropoietin Mus musculus
3 It was found that whereas Epo-stimulated growth was markedly inhibited by cAMP-enhancing agents, IL-3-stimulated growth was relatively resistant and inhibited only by high doses of these agents. Cyclic AMP erythropoietin Mus musculus