Title : Defects in TLR3 expression and RNase L activation lead to decreased MnSOD expression and insulin resistance in muscle cells of obese people.

Pub. Date : 2014 Mar 20

PMID : 24651439






1 Functional Relationships(s)
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1 Increased expression of RNase L or downregulation of its inhibitor (RLI) improved insulin response in mouse myogenic C2C12 cells and in primary human myotubes from normal-weight subjects treated with palmitate, a saturated free fatty acid (FFA) known to induce inflammation and oxidative stress via TLR4 activation. saturated free fatty acid ATP-binding cassette, sub-family E (OABP), member 1 Mus musculus