Pub. Date : 2013 Mar
PMID : 24649171
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sanguinarine is a novel VEGF inhibitor involved in the suppression of angiogenesis and cell migration. | sanguinarine | vascular endothelial growth factor A | Homo sapiens |
| 2 | In the present study, it was demonstrated that sanguinarine, an alkaloid obtained from the bloodroot plant, markedly repressed the VEGF-induced tube formation of human microvascular endothelial cells (HMVECs) and the migration of human A549 lung cancer cells. | sanguinarine | vascular endothelial growth factor A | Homo sapiens |
| 3 | Furthermore, sanguinarine decreased VEGF secretion and expression in HMVECs and A549 lung cancer cells in a dose- and time-dependent manner. | sanguinarine | vascular endothelial growth factor A | Homo sapiens |
| 4 | Additionally, sanguinarine inhibited the activation of serum starvation- and hypoxia-induced VEGF promoter activity. | sanguinarine | vascular endothelial growth factor A | Homo sapiens |
| 5 | Sanguinarine also inhibited the VEGF-mediated Akt and p38 activation, as well as VE-cadherin protein phosphorylation. | sanguinarine | vascular endothelial growth factor A | Homo sapiens |
| 6 | To the best of our knowledge, this is the first study demonstrating that VEGF inhibition appears to be an important mechanism involved in the antiangiogenic and anti-invasive activities of sanguinarine in lung cancer treatment. | sanguinarine | vascular endothelial growth factor A | Homo sapiens |