Title : Estrogen combined with progesterone decreases cell proliferation and inhibits the expression of Bcl-2 via microRNA let-7a and miR-34b in ovarian cancer cells.

Pub. Date : 2014 Oct

PMID : 24643702






3 Functional Relationships(s)
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1 E(2) + P4 promoted the expression of let-7a and miR-34b and reduced the expression of Bcl-2 in ovarian cancer cells. e(2) + p4 microRNA 34b Homo sapiens
2 When the expression of let-7a or/and miR-34b was inhibited using miRNA inhibitors, E(2) + P4 treatment did not change the protein level of Bcl-2. e(2) + p4 microRNA 34b Homo sapiens
3 CONCLUSION: E(2) + P4 significantly inhibited the cell survival, promoted the cell apoptosis, induced the expression of let-7a and miR-34b, and reduced the expression of Bcl-2 in ovarian cancer cells. e(2) + p4 microRNA 34b Homo sapiens