Title : Silencing of hepcidin enforces the apoptosis in iron-induced human cardiomyocytes.

Pub. Date : 2014 Mar 18

PMID : 24641804






2 Functional Relationships(s)
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1 This iron-induced apoptosis was linked to enhanced caspase 8, reduced Bcl-2, Bcl-xL, phosphorylated Akt and GATA-4. Iron AKT serine/threonine kinase 1 Homo sapiens
2 In iron pretreated cardiomyocytes, the siRNA2 transfection further increased caspase 8 expression and decreased the expression of GATA-4, Bcl-2, Bcl-xL and phosphorylated Akt than iron pretreatment alone, but caspase 9 levels remained unchanged. Iron AKT serine/threonine kinase 1 Homo sapiens