Title : Glucocorticoid receptor activation impairs hippocampal plasticity by suppressing BDNF expression in obese mice.

Pub. Date : 2014 Apr

PMID : 24636513






3 Functional Relationships(s)
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1 Synaptic deficits evoked by exposure to elevated corticosterone levels in db/db mice are attributable to glucocorticoid receptor-mediated transrepression of AP-1 actions at BDNF promoters I and IV. Corticosterone brain derived neurotrophic factor Mus musculus
2 db/db mice exhibit corticosterone-mediated reductions in brain-derived neurotrophic factor (BDNF), and a change in the ratio of TrkB to P75NTR that silences the functional response to BDNF stimulation. Corticosterone brain derived neurotrophic factor Mus musculus
3 db/db mice exhibit corticosterone-mediated reductions in brain-derived neurotrophic factor (BDNF), and a change in the ratio of TrkB to P75NTR that silences the functional response to BDNF stimulation. Corticosterone brain derived neurotrophic factor Mus musculus