Title : Atomic basis of CRM1-cargo recognition, release and inhibition.

Pub. Date : 2014 Aug

PMID : 24631835






1 Functional Relationships(s)
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1 Numerous atomic resolution CRM1 structures are now available, explaining how the exporter recognizes nuclear export signals in its cargos, how RanGTP and cargo bind with positive cooperativity, how RanBP1 causes release of export cargos in the cytoplasm and how diverse inhibitors such as Leptomycin B and the new KPT-SINE compounds block nuclear export. leptomycin B exportin 1 Homo sapiens