Title : Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents.

Pub. Date : 2014 Aug

PMID : 24631834






1 Functional Relationships(s)
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1 Clinical trials using the classic CRM1 inhibitor leptomycin B proved too toxic for patients; however, a new generation of less toxic small molecule inhibitors is being used in clinical trials in patients with both hematological malignancies and solid tumors. leptomycin B exportin 1 Homo sapiens