Title : Melatonin reduces endothelin-1 expression and secretion in colon cancer cells through the inactivation of FoxO-1 and NF-κβ.

Pub. Date : 2014 May

PMID : 24628039






1 Functional Relationships(s)
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1 The data presented show that melatonin inhibits edn-1 mRNA expression (the first step in ET-1 synthesis), ECE-1 protein expression and the release of ET-1 from colorectal cancer cells in vitro. Melatonin endothelin converting enzyme 1 Homo sapiens