Title : Aprotinin derivatives with chromophoric leaving groups can be used as highly selective active-site titrants for serine proteinases and permit the determination of kinetic constants of enzyme-inhibitor complexes.

Pub. Date : 1988 Dec 2

PMID : 2461739






1 Functional Relationships(s)
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1 Serine proteinases with suitable specificity are able to remove 4-nitroaniline or 7-amino-4-methylcoumarin from these aprotinin derivatives while at the same time resynthesis of the reactive-site peptide bond occurs. 4-nitroaniline pancreatic trypsin inhibitor Bos taurus