Title : Pharmacophore and binding analysis of known and novel B-RAF kinase inhibitors.

Pub. Date : 2014 Jun

PMID : 24606495






3 Functional Relationships(s)
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1 The docking and assay results support our conclusion that the presented compound family belongs to the type I 1/2 subgroup, they inhibit B-RAF and B-RAF(V600E) mutant in a sub-micromolar range and most of them show selectivity towards B-RAF(V600E) mutant expressing cell lines with equal or even better IC50 values than sorafenib. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens
2 The docking and assay results support our conclusion that the presented compound family belongs to the type I 1/2 subgroup, they inhibit B-RAF and B-RAF(V600E) mutant in a sub-micromolar range and most of them show selectivity towards B-RAF(V600E) mutant expressing cell lines with equal or even better IC50 values than sorafenib. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens
3 The docking and assay results support our conclusion that the presented compound family belongs to the type I 1/2 subgroup, they inhibit B-RAF and B-RAF(V600E) mutant in a sub-micromolar range and most of them show selectivity towards B-RAF(V600E) mutant expressing cell lines with equal or even better IC50 values than sorafenib. Sorafenib zinc fingers and homeoboxes 2 Homo sapiens