Title : Mutagenesis of aspartic acid-116 enhances the ribonucleolytic activity and angiogenic potency of angiogenin.

Pub. Date : 1988 Oct

PMID : 2459697






2 Functional Relationships(s)
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1 Replacement of Asp-116 in angiogenin by either asparagine (D116N), alanine (D116A), or histidine (D116H) markedly enhances both its ribonucleolytic activity and angiogenic potency. Histidine ribonuclease A family member k6 Gallus gallus
2 Thus, cleavage of 18S and 28S rRNA by the most active His-116 mutant yields the same pattern of polynucleotide products as from angiogenin, whereas there are only minor alterations in activity with cytidylyl(3",5")adenosine and uridylyl(3",5")-adenosine. Histidine ribonuclease A family member k6 Gallus gallus