Title : Redox cycling of bleomycin-Fe(III) and DNA degradation by isolated NADH-cytochrome b5 reductase: involvement of cytochrome b5.

Pub. Date : 1988 Oct

PMID : 2459594






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Isolated and purified microsomal NADH-cytochrome b5 reductase (EC 1.6.2.2) was incubated with bleomycin (BLM) and FeCl3 in the presence of NADH. NAD cytochrome b5 type A Homo sapiens
2 Only when purified cytochrome b5 was added could an increased NADH consumption be observed indicating redox cycling of the BLM-Fe(III) complex. NAD cytochrome b5 type A Homo sapiens
3 The results reveal that the BLM-Fe(III) complex undergoes redox cycling by the microsomal NADH-dependent cytochrome b5 reductase-cytochrome b5 system. NAD cytochrome b5 type A Homo sapiens
4 The results reveal that the BLM-Fe(III) complex undergoes redox cycling by the microsomal NADH-dependent cytochrome b5 reductase-cytochrome b5 system. NAD cytochrome b5 type A Homo sapiens