Title : Periadventitial application of rapamycin-loaded nanoparticles produces sustained inhibition of vascular restenosis.

Pub. Date : 2014

PMID : 24586612






2 Functional Relationships(s)
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1 In cultured rat vascular smooth muscle cells (SMCs), rapamycin-loaded NPs produced durable (14 days versus 3 days for free rapamycin) inhibition of phosphorylation of S6 kinase (S6K1), a downstream target in the mTOR pathway. Sirolimus ribosomal protein S6 kinase B1 Rattus norvegicus
2 In cultured rat vascular smooth muscle cells (SMCs), rapamycin-loaded NPs produced durable (14 days versus 3 days for free rapamycin) inhibition of phosphorylation of S6 kinase (S6K1), a downstream target in the mTOR pathway. Sirolimus ribosomal protein S6 kinase B1 Rattus norvegicus