Title : Inhibition of Gαi activity by Gβγ is mediated by PI 3-kinase-γ- and cSrc-dependent tyrosine phosphorylation of Gαi and recruitment of RGS12.

Pub. Date : 2014 May 1

PMID : 24578342






1 Functional Relationships(s)
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1 The Gi2-coupled delta-opioid receptor agonist d-penicillamine (2,5)-enkephalin (DPDPE) activated cSrc, stimulated tyrosine phosphorylation of Galphai2, and induced regulator of G protein signaling 12 (RGS12) association; all three events were blocked by PI 3-kinase (LY294002) and cSrc (PP2) inhibitors and by expression of the COOH-terminal sequence of GRK2-(495-689), a Gbetagamma-scavenging peptide. Penicillamine neuropeptide Y receptor Y6 (pseudogene) Homo sapiens