Title : Akt and mTOR mediate programmed necrosis in neurons.

Pub. Date : 2014 Feb 27

PMID : 24577082






1 Functional Relationships(s)
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1 TNFalpha/zVAD treatment induced cell death within 4 h. Cell death was preceded by RIPK1-RIPK3-pAkt assembly, and phosphorylation of Thr-308 and Thr473 of AKT and its direct substrate glycogen synthase kinase-3beta, as well as mTOR and its direct substrate S6 ribosomal protein (S6), suggesting activation of Akt/mTOR pathways. benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone receptor-interacting serine-threonine kinase 3 Mus musculus