Pub. Date : 2014 Mar 14
PMID : 24576478
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4. | Cholesterol | microRNA 205 | Homo sapiens |
| 2 | Strikingly, we found that HBx was able to increase the levels of cellular cholesterol, a metabolite of ACSL4, in hepatoma cells, which could be blocked by miR-205 (or Triacsin C, an inhibitor of ACSL4). | Cholesterol | microRNA 205 | Homo sapiens |
| 3 | However, anti-miR-205 could increase the levels of cholesterol in the cells. | Cholesterol | microRNA 205 | Homo sapiens |
| 4 | The HBx-depressed miR-205 is responsible for the abnormal lipid metabolism through accumulating cholesterol in hepatoma cells. | Cholesterol | microRNA 205 | Homo sapiens |