Title : Monoclonal IgM in two patients with motor neuron disease bind to the carbohydrate antigens Gal(beta 1-3)GalNAc and Gal(beta 1-3)GlcNAc.

Pub. Date : 1988 Sep

PMID : 2457603






2 Functional Relationships(s)
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1 In this study we show that the serum IgM from both patients bind to bovine serum albumin (BSA) glycoconjugates of both Gal(beta 1-3)GalNAc and Gal(beta 1-3)GlcNAc. N-acetylgalactosaminuronic acid eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens
2 Low levels of antibodies to Gal(beta 1-3)GlcNAc-BSA and to Gal(beta 1-3)GlcNAc-BSA were also detected in patients with amyotrophic lateral sclerosis (ALS) and in normal subjects at serum dilutions of up to 1:500, but these did not have the same specificity as the M-proteins, as binding to Gal(beta 1-3)GalNAc-BSA was not inhibited by absorption with Gal(beta 1-3)GlcNAc-BSA. N-acetylgalactosaminuronic acid eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens