Title : Mutation of 3-hydroxy-3-methylglutaryl CoA synthase I reveals requirements for isoprenoid and cholesterol synthesis in oligodendrocyte migration arrest, axon wrapping, and myelin gene expression.

Pub. Date : 2014 Feb 26

PMID : 24573296






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Through a forward genetic screen in zebrafish we discovered that mutation of hmgcs1, which encodes an enzyme necessary for isoprenoid and cholesterol synthesis, causes oligodendrocyte progenitor cells (OPCs) to migrate past their target axons and to fail to express myelin genes. Cholesterol 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Danio rerio