Title : Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-κB activation, and is active in patient-derived xenograft models.

Pub. Date : 2014 Apr

PMID : 24563541






3 Functional Relationships(s)
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1 Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-kappaB activation, and is active in patient-derived xenograft models. birinapant TNF receptor associated factor 2 Homo sapiens
2 Birinapant (TL32711), a bivalent SMAC mimetic, targets TRAF2-associated cIAPs, abrogates TNF-induced NF-kappaB activation, and is active in patient-derived xenograft models. birinapant TNF receptor associated factor 2 Homo sapiens
3 Birinapant preferentially targeted the TRAF2-associated cIAP1 and cIAP2 with subsequent inhibition of TNF-induced NF-kappaB activation. birinapant TNF receptor associated factor 2 Homo sapiens