Title : A new epitope on human myelin basic protein arising from cleavage by a metalloendoprotease associated with brain myelin membranes.

Pub. Date : 1988 Aug

PMID : 2456309






1 Functional Relationships(s)
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1 After treatment with pyroglutamyl aminopeptidase, N-terminal sequencing indicated that Gln74 of MBP formed the N-terminal residue of peptide C. A rabbit antiserum was raised to a synthetic peptide containing the sequence Pyroglu-Lys-Ser-His-Gly-Arg, corresponding to the first six residues of peptide C. By immunoblotting this serum reacted with peptide C but not with intact MBP. Glycine myelin basic protein Homo sapiens