Title : Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity.

Pub. Date : 2014 Apr 6

PMID : 24561005






3 Functional Relationships(s)
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1 Of the 1,3-butadiene-derived metabolites studied, 3,4-epoxy-1-butene was the strongest inhibitor with an IC50 of 110 muM compared to 1700 muM and 6600 muM for 1,2-butenediol and 1,2:3,4-diepoxybutane, respectively. 1,3-butadiene latexin Homo sapiens
2 Of the 1,3-butadiene-derived metabolites studied, 3,4-epoxy-1-butene was the strongest inhibitor with an IC50 of 110 muM compared to 1700 muM and 6600 muM for 1,2-butenediol and 1,2:3,4-diepoxybutane, respectively. 1,3-butadiene latexin Homo sapiens
3 Of the 1,3-butadiene-derived metabolites studied, 3,4-epoxy-1-butene was the strongest inhibitor with an IC50 of 110 muM compared to 1700 muM and 6600 muM for 1,2-butenediol and 1,2:3,4-diepoxybutane, respectively. 1,3-butadiene latexin Homo sapiens