Pub. Date : 2014 Mar 15
PMID : 24560738
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Among the 7-hex-5-ynyloxy-coumarins, the 3-methoxycarbonyl derivative 36 was characterized as a dual-acting inhibitor with IC50 values of less than 10 nM towards MAO-A and MAO-B, and the 3-(4-methoxy)phenyl derivative 44 was shown to combine strong anti-MAO-B potency (IC50=3.0 nM) and selectivity for MAO-B over MAO-A (selectivity >3400-fold). | 7-hex-5-ynyloxy-coumarins | monoamine oxidase B | Homo sapiens |
| 2 | Among the 7-hex-5-ynyloxy-coumarins, the 3-methoxycarbonyl derivative 36 was characterized as a dual-acting inhibitor with IC50 values of less than 10 nM towards MAO-A and MAO-B, and the 3-(4-methoxy)phenyl derivative 44 was shown to combine strong anti-MAO-B potency (IC50=3.0 nM) and selectivity for MAO-B over MAO-A (selectivity >3400-fold). | 7-hex-5-ynyloxy-coumarins | monoamine oxidase B | Homo sapiens |
| 3 | Among the 7-hex-5-ynyloxy-coumarins, the 3-methoxycarbonyl derivative 36 was characterized as a dual-acting inhibitor with IC50 values of less than 10 nM towards MAO-A and MAO-B, and the 3-(4-methoxy)phenyl derivative 44 was shown to combine strong anti-MAO-B potency (IC50=3.0 nM) and selectivity for MAO-B over MAO-A (selectivity >3400-fold). | 7-hex-5-ynyloxy-coumarins | monoamine oxidase B | Homo sapiens |