Title : Antipsychotic agent thioridazine sensitizes renal carcinoma Caki cells to TRAIL-induced apoptosis through reactive oxygen species-mediated inhibition of Akt signaling and downregulation of Mcl-1 and c-FLIP(L).

Pub. Date : 2014 Feb 20

PMID : 24556678






1 Functional Relationships(s)
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1 Furthermore, thioridazine increased the production of reactive oxygen species (ROS) in Caki cells, and ROS scavengers (N-acetylcysteine, glutathione ethyl ester, and trolox) inhibited thioridazine plus TRAIL-induced apoptosis, as well as Akt inhibition and the downregulation of c-FLIP(L) and Mcl-1. 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid AKT serine/threonine kinase 1 Homo sapiens