Title : Identification of glucuronidation and biliary excretion as the main mechanisms for gossypol clearance: in vivo and in vitro evidence.

Pub. Date : 2014 Aug

PMID : 24555821






2 Functional Relationships(s)
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1 In bile duct cannulated rats, considerable amounts of glucuronides (G1, G2 and G3; 58.8-83.2% of dose) and parent compound (5.0-20%) were excreted into bile after IV administration. Glucuronides myosin light chain, phosphorylatable, fast skeletal muscle Rattus norvegicus
2 Significant amounts of glucuronides (G1, G2 and G3) were excreted into the gut lumen (2.5%) and into the bile (4.8%). Glucuronides myosin light chain, phosphorylatable, fast skeletal muscle Rattus norvegicus