Title : Ponatinib induces apoptosis in imatinib-resistant human mast cells by dephosphorylating mutant D816V KIT and silencing β-catenin signaling.

Pub. Date : 2014 May

PMID : 24552773






1 Functional Relationships(s)
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1 Furthermore, ponatinib abrogated the phosphorylation of beta-catenin at the site Y654, suppressed the translocation of beta-catenin, and inhibited the transcription and DNA binding of TCF and the expression of its targets (e.g., AXIN2, c-MYC, and CCND1). ponatinib cyclin D1 Homo sapiens