Title : HES5 is a key mediator of Wnt-3a-induced neuronal differentiation.

Pub. Date : 2014 Jun 15

PMID : 24548083






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Remarkably, HES5 overexpression efficiently blocked Wnt-3a as well as gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT)-induced neuronal differentiation that was accompanied by a strong MASH1 downregulation thus directly linking HES5 repression/MASH1 induction to the proneurogenic effect of Wnt-3a. dapt hes family bHLH transcription factor 5 Homo sapiens
2 Remarkably, HES5 overexpression efficiently blocked Wnt-3a as well as gamma-secretase inhibitor N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT)-induced neuronal differentiation that was accompanied by a strong MASH1 downregulation thus directly linking HES5 repression/MASH1 induction to the proneurogenic effect of Wnt-3a. dapt hes family bHLH transcription factor 5 Homo sapiens