Title : α-Tocopheryl Succinate Inhibits Osteoclast Formation by Suppressing Receptor Activator of Nuclear Factor-kappaB Ligand (RANKL) Expression and Bone Resorption.

Pub. Date : 2012 Nov

PMID : 24524041






2 Functional Relationships(s)
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1 RESULTS: alphaTP-suc inhibits osteoclast formation in cocultures stimulated by IL-1 and decreased the level of expression of RANKL mRNA in osteoblasts. alpha-Tocopherol interleukin 1 complex Mus musculus
2 In addition, administered intraperitoneal injections of alphaTP-suc prevented IL-1-mediated osteoclast formation and bone loss in vivo. alpha-Tocopherol interleukin 1 complex Mus musculus