Title : Anti-arthritis effects of (E)-2,4-bis(p-hydroxyphenyl)-2-butenal are mediated by inhibition of the STAT3 pathway.

Pub. Date : 2014 Jun

PMID : 24520814






3 Functional Relationships(s)
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1 A pull-down assay showed that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal interfered with binding of ATP to STAT3. Adenosine Triphosphate signal transducer and activator of transcription 3 Mus musculus
2 Docking studies suggested that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal bound to the DNA-binding interface of STAT3 possibly inhibiting ATP binding to STAT3 in an allosteric manner. Adenosine Triphosphate signal transducer and activator of transcription 3 Mus musculus
3 Docking studies suggested that (E)-2,4-bis(p-hydroxyphenyl)-2-butenal bound to the DNA-binding interface of STAT3 possibly inhibiting ATP binding to STAT3 in an allosteric manner. Adenosine Triphosphate signal transducer and activator of transcription 3 Mus musculus