Pub. Date : 1988 Mar 15
PMID : 2450745
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dual mechanism of phosphatidylinositol hydrolysis by substance P in brain. | Phosphatidylinositols | tachykinin precursor 1 | Homo sapiens |
| 2 | These results are consistent with the phosphatidylinositol breakdown caused by substance P in some tissues. | Phosphatidylinositols | tachykinin precursor 1 | Homo sapiens |
| 3 | Thus, in the presence of very low doses of substance P (65 pM) a preferential degradation of 1-acyl(predominantly stearoyl)-2-arachidonoylglycerophosphoinositol molecular species occurs, whereas high doses of the peptide (0.65 microM) induce a generalized hydrolysis of phosphatidylinositol without showing any preference towards molecular species rich in arachidonic acid. | Phosphatidylinositols | tachykinin precursor 1 | Homo sapiens |
| 4 | Hence we describe for the first time a dual, dose-dependent mechanism for phosphatidylinositol hydrolysis by substance P, suggesting the possibility that either phospholipase A2 or phospholipase C activation is involved. | Phosphatidylinositols | tachykinin precursor 1 | Homo sapiens |