Title : Curcumin implants, not curcumin diet, inhibit estrogen-induced mammary carcinogenesis in ACI rats.

Pub. Date : 2014 Apr

PMID : 24501322






1 Functional Relationships(s)
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1 Because CYP1A and CYP3A4 metabolize most of the E2 to its noncarcinogenic 2-OH metabolite, and CYP1B1 produces potentially carcinogenic 4-OH metabolite, favorable modulation of these CYPs via systemically delivered curcumin could be one of the potential mechanisms. 4-oh cytochrome P450, family 1, subfamily b, polypeptide 1 Rattus norvegicus