Pub. Date : 2014 Oct
PMID : 24499675
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells. | arsenite | tumor protein p53 | Homo sapiens |
| 2 | In this study, we investigate whether arsenite-induced DNA damage leads to p53-dependent premature senescence using human glioblastoma cells with p53-wild type (U87MG-neo) and p53 deficient (U87MG-E6). | arsenite | tumor protein p53 | Homo sapiens |
| 3 | This suggests that arsenite induces premature senescence as a result of DNA damage with heterochromatin forming through a p53/p21 dependent pathway. | arsenite | tumor protein p53 | Homo sapiens |
| 4 | Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage. | arsenite | tumor protein p53 | Homo sapiens |
| 5 | Taken together, arsenite reduces cell growth independently of p53 and induces premature senescence via p53/p21-dependent pathway following DNA damage. | arsenite | tumor protein p53 | Homo sapiens |