Title : An MTHFR variant, plasma homocysteine levels and late-onset coronary artery disease in subjects from southern Iran.

Pub. Date : 2013 Aug 15

PMID : 24498831






3 Functional Relationships(s)
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1 Furthermore, an alanine/valine (Ala/Val) gene polymorphism at 222nd amino acid of 5,10-methylenetetrahydrofolate reductase (MTHFR) has been considered as a factor that could render this enzyme thermolabile and less active which in turn may yield a subsequent increase in plasma total homocysteine (tHcy) levels. thcy methylenetetrahydrofolate reductase Homo sapiens
2 Furthermore, an alanine/valine (Ala/Val) gene polymorphism at 222nd amino acid of 5,10-methylenetetrahydrofolate reductase (MTHFR) has been considered as a factor that could render this enzyme thermolabile and less active which in turn may yield a subsequent increase in plasma total homocysteine (tHcy) levels. thcy methylenetetrahydrofolate reductase Homo sapiens
3 Moreover, as the multiple linear regression analysis indicated, smoking habit, folate levels and the MTHFR Val/Val genotype were the only major predictors of tHcy concentrations in the current investigation. thcy methylenetetrahydrofolate reductase Homo sapiens