Title : Dovitinib synergizes with oxaliplatin in suppressing cell proliferation and inducing apoptosis in colorectal cancer cells regardless of RAS-RAF mutation status.

Pub. Date : 2014 Feb 4

PMID : 24495750






2 Functional Relationships(s)
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1 RESULTS: The combination of dovitinib and oxaliplatin showed higher in vitro cytotoxicity in colon cell lines irrespective of their RAS-RAF status as compared to either of the drugs alone. Oxaliplatin zinc fingers and homeoboxes 2 Homo sapiens
2 CONCLUSIONS: This study demonstrates the synergistic antitumor activity of combination of dovitinib and oxaliplatin against colon cancer with different RAS-RAF status. Oxaliplatin zinc fingers and homeoboxes 2 Homo sapiens