Title : Aurora-A controls cancer cell radio- and chemoresistance via ATM/Chk2-mediated DNA repair networks.

Pub. Date : 2014 May

PMID : 24480460






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Treatment of cells overexpressing Aurora-A and ATM/Chk2 with the ATM specific inhibitor KU-55933 increased the cell sensitivity to cisplatin and irradiation through increasing the phosphorylation of p53 at Ser15 and inhibiting the expression of Chk2, gammaH2AX (Ser319), and RAD51. gammah2ax tumor protein p53 Homo sapiens