Title : Nearly 50 years in the making: defining the catalytic mechanism of the multifunctional enzyme, pyruvate carboxylase.

Pub. Date : 2014 Mar

PMID : 24476417






1 Functional Relationships(s)
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1 Through initial velocity, product inhibition, isotopic exchange and alternate substrate experiments, early investigators established that PC catalyzes the MgATP-dependent carboxylation of pyruvate by HCO3 (-) through a nonclassical sequential Bi Bi Uni Uni reaction mechanism. Pyruvic Acid pyruvate carboxylase Homo sapiens